C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/32 (2006.01) A61K 31/17 (2006.01) A61K 31/395 (2006.01) A61P 13/00 (2006.01) A61P 29/00 (2006.01) C07C 275/40 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 211/62 (2006.01) C07D 295/12 (2006.01) C07D 295/135 (2006.01)
Patent
CA 2508845
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
L'invention concerne des dérivés tétrahydro-naphtalène et des sels de ceux-ci utiles en tant que principe actif de préparations pharmaceutiques. Ces dérivés tétrahydro-naphtalène présentent une excellente activité en tant qu'antagoniste du VR1 et sont utiles pour la prophylaxie et le traitement de maladies associées à l'activité du VR1, en particulier pour le traitement de l'incontinence urinaire, l'incontinence urinaire d'urgence, la suractivité de la vessie, la douleur chronique, la douleur neuropathique, la douleur postopératoire, la polyarthrite rhumatismale, la névralgie, les neuropathies, l'algésie, les lésions nerveuses, l'ischémie, la neurodégénération, les accidents vasculaires cérébraux, les troubles inflammatoires, l'asthme et les maladies obstructives respiratoires.
Fujishima Hiroshi
Kokubo Toshio
Masuda Tsutomu
Mogi Muneto
Moriwaki Toshiya
Bayer Healthcare Ag
Fetherstonhaugh & Co.
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