C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01) A61K 35/00 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2389117
The invention relates to compositions and methods for enhancing the developmental potential of oocytes or zygotes by increasing intracellular levels of replicative mitochondria in the oocytes or zygotes. In one aspect of the invention, the intracellular levels of replicative mitochondria are increased by introducing replicative mitochondria into the oocytes or zygotes. The oocytes may be fertilized to obtain a zygote with increased intracellular levels of replicative mitochondria. The methods and compositions may be used to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques.
L'invention concerne des compositions et des procédés améliorant le potentiel de développement d'oocytes ou de zygotes par augmentation des niveaux intracellulaires de mitochondries réplicatives dans les oocytes ou les zygotes. Selon un aspect de l'invention, les niveaux intracellulaires de mitochondries réplicatives sont augmentés par introduction de mitochondries réplicatives dans les oocytes ou les zygotes. Les oocytes peuvent être fécondés afin d'obtenir un zygote à niveaux intracellulaires augmentés de mitochondries réplicatives. On peut utiliser les procédés et compositions selon l'invention pour améliorer les procédés de fécondation in vitro et de transfert d'embryon, ainsi que les techniques de transfert de matériel nucléaire.
Casper Robert F.
Jurisicova Andrea
Perez Gloria I.
Rogers Ian
Tilly Jonathan
Mount Sinai Hospital
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The General Hospital Corporation D/b/a Massachusetts General Hos
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