Drug polymer complexes

A - Human Necessities – 61 – K

Patent

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A61K 9/14 (2006.01)

Patent

CA 2529503

This invention relates to polymeric complexes of drugs to be employed as (or in) sustained release-formulations comprising a cationic active agent, and a polyanionic water soluble complexing polymer of sufficient molecular weight that it for-ins a gel when mixed with said active agent. The invention also relates to the manufacture of such sustained release compositions and their many uses. Also included is a molded prosthesis comprising a prosthesis including a sustained release composition comprising a cationic anti-infective and a complexing polymer.

L'invention concerne des complexes polymères de médicaments destinés à être employés comme (ou dans des) formulations à libération prolongée, comprenant un agent actif cationique, et un polymère complexant soluble dans l'eau, polyanionique, d'un poids moléculaire suffisant, formant un gel lorsqu'il est mélangé avec ledit agent actif. L'invention concerne également la fabrication de telles compositions à libération prolongée, ainsi que leurs utilisations. En outre, l'invention concerne une prothèse moulée comprenant une prothèse contenant une composition à libération prolongée comprenant un agent anti-infectieux cationique et un polymère complexant.

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