C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/82 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 213/81 (2006.01) C07D 215/48 (2006.01) C07D 239/74 (2006.01) C07D 241/44 (2006.01) C07D 261/18 (2006.01) C07D 277/68 (2006.01) C07D 333/38 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2338121
The invention concerns amide derivatives of formula (I) wherein R3 is (1- 6C)alkyl or halogeno; Q1 is heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1- 6C)alkyl, (1-6C)alkoxy, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, hydroxy- (2-6C)alkoxy, amino-(2-6C)alkylamino, <u>N</u>-(1-6C)alkyl-(1-6C)alkylamino-(2- 6C)alkylamino, aryl, heteroaryl and heterocyclyl; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and Q2 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically- acceptable salts or in vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
L'invention concerne des dérivés d'amides représentés par la formule (I) dans laquelle R?3¿ est l'alkyle (C1-6) ou halogéno; Q?1¿ est l'hétéroalkyle éventuellement substitué par 1, 2, 3 ou 4 substituants tels qu'hydroxy, halogéno, trifluorométhyle, alkyle (C1-6), alcoxy (C1-6), hydroxyalkyle (C1-6), alcoxy(C1-6)-alkyle(C1-6), hydroxy-alcoxy (C2-6), amino-alkyl(C2-6)amino, <u>N</u>-alkyl(C1-6)alkyl(C1-6)amino-alkyl(C2-6)amino, aryle, hétéroaryle, hétérocyclyle; p est 0-2 et R?2¿ est un substituant tel qu'hydroxy ou halogéno; q est 0-4; et Q?2¿ comprend l'aryle, le cycloalkyle, l'hétéroalkyle et l'hétérocyclyle éventuellement substitués; ou des sels pharmaceutiquement acceptables ou des esters clivables <u>in vivo</u> de ces dérivés. L'invention concerne également des procédés permettant la préparation de ces dérivés, des compositions pharmaceutiques les contenant, ainsi que l'utilisation de ces dérivés pour le traitement de pathologies ou de troubles médicaux à médiation de cytokines.
Brown Dearg Sutherland
Brown George Robert
Astrazeneca Ab
Smart & Biggar
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