C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/14 (2006.01) A61K 31/4427 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4995 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/16 (2006.01) C07D 213/81 (2006.01) C07D 215/16 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.0
Patent
CA 2742297
The present invention provides novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders relating to aging or stress, diabetes, obesity, neurodegenerative disease, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorder that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. The compounds are of general formula (III) wherein R1, R2, R", X, Y, W, Z1 and Z2 are as defined in the specification.
La présente invention concerne de nouveaux composés modulateurs de sirtuine et des procédés dutilisation de ceux-ci. Les composés modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie dune cellule, et traiter et/ou prévenir une grande variété de maladies et troubles associés au vieillissement ou au stress, le diabète, lobésité, une maladie neurodégénérative, une maladie cardiovasculaire, des troubles de la coagulation sanguine, linflammation, le cancer, et/ou les bouffées congestives ainsi que des maladies ou troubles qui bénéficieraient dune activité mitochondriale augmentée. La présente invention concerne en outre des compositions comprenant un composé modulateur de sirtuine en combinaison avec un autre agent thérapeutique. Les composés sont de formule générale (III) dans laquelle R1, R2, R", X, Y, W, Z1 et Z2 sont tels que définis dans la spécification.
Disch Jeremy S.
Narayan Radha
Perni Robert B.
Vu Chi B.
Gowling Lafleur Henderson Llp
Sirtris Pharmaceuticals Inc.
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