C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01) A61K 31/445 (2006.01)
Patent
CA 2347469
The present invention is directed to esters of (+)-.alpha.-(2,3- Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, of formula (I) wherein R is C4-C20alkyl, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT2A, receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
L'invention concerne des esters de (+)-alpha-(2,3-diméthoxyphényl)-1-[2-(4-fluorophényl)éthyl]-4-pipéridineméthanol de formule (I) dans laquelle R représente un alkyle C4-C20, des formulations pharmaceutiques, des procédés de préparation et d'utilisation de ces esters. Ces composés antagonisent les effets de la sérotonine au niveau du récepteur de 5HT2A et sont utilisés dans le traitement de différentes pathologies, dont notamment les psychoses telles que la schizophrénie.
Carr Albert A.
Kosley Raymond W. Jr.
Van Hijfte Luc E.
Aventis Holdings Inc.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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