4-aminoquinazoline derivatives and methods of use thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/10 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2661223

This invention relates to novel 4-aminoquinazolines, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of the EGFR and HER-2.

La présente invention concerne de nouveaux composés à base de 4-aminoquinazoline, leurs dérivés, leurs sels, solvates, et hydrates pharmaceutiquement acceptables. L'invention concerne également des compositions comprenant un composé selon l'invention et l'utilisation de telles compositions dans des procédés de traitement de maladies et de conditions pathologiques pour lesquelles l'administration d'inhibiteurs de EFGR et de HER2 est bénéfique.

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