Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/06 (2006.01) A61K 31/4155 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/4995 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2571824

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des composés de dihydropyrazole qui sont utilisés dans le traitement de maladies proliférantes cellulaires pour traiter les troubles associées à l'activité de kinésine KSP et pour inhiber la kinésine KSP. L'invention concerne aussi des compositions qui comprennent ces composés et des procédés de leur utilisation dans le traitement du cancer chez les mammifères.

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