Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as...

Details Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as... Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as...

C - Chemistry, Metallurgy

07

D

C07D 241/44 (2006.01) A61K 31/498 (2006.01) A61P 1/04 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 3/14 (2006.01) A61P 5/50 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2687948

Disclosed is a compound represented by the general formula (1) or a salt thereof, which is useful as a modulator for a glucocorticoid receptor. In the formula, R1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group or the like; R2 represents a hydrogen atom, a lower alkyl group or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; R4 and R5 independently represent a hydrogen atom, a lower alkyl group or the like; R6 represents a hydrogen atom, a lower alkyl group or the like; R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group or the like; W represents an oxygen atom, a sulfur atom, NR8 or the like; R8 represents a hydrogen atom, a lower alkyl group or the like; X represents an oxygen atom or a sulfur atom; Y represents a lower alkylene group or the like; Z represents an oxygen atom, a sulfur atom, NR9, OCO or OSO2; and R9 represents a hydrogen atom, a lower alkyl group or the like.

La présente invention concerne un composé représenté par la formule générale (1) ou l'un de ses sels, qui est utile en tant que modulateur d'un récepteur de glucocorticoïde. Dans la formule, R1 représente un groupe alkyle inférieur, un groupe cycloalkyle inférieur, un groupe aryle ou analogues; R2 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues; R3 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues; R4 et R5 représentent indépendamment un atome d'hydrogène, un groupe alkyle inférieur ou analogues; R6 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues; R7 représente un atome d'hydrogène, un groupe alkyle inférieur, un groupe alcényle inférieur ou analogues; W représente un atome d'oxygène, un atome de soufre, NR8 ou analogues; R8 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues; X représente un atome d'oxygène ou un atome de soufre; Y représente un groupe alkylène inférieur ou analogues; Z représente un atome d'oxygène, un atome de soufre, NR9, OCO ou OSO2; et R9 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues.

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