Epididymal antimicrobial peptides

Details Epididymal antimicrobial peptides Epididymal antimicrobial peptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2396364

The present invention provides novel antimicrobial peptides expressed in the primate epididymis (hereinafter, "EP2 peptides") and the nucleic acids encoding therefore. EP2 peptides and the nucleic acids encoding therefore can be administered to an individual having a microbial infection in an amount effective to treat the microbial infection or the endogenous production of EP2 peptides can be upregulated to an amount effective to treat the microbial infection. EP2 peptides are useful as antimicrobial agents in animals, including humans, and as antimicrobial agents in agricultural and industrial applications.

L'invention concerne de nouveaux peptides antimicrobiens exprimés dans l'épididyme du primate (dénommés "peptides EP2"), ainsi que les acides nucléiques les codant. Ces peptides EP2 et les acides nucléiques les codant peuvent être administrés à un individu atteint d'une infection microbienne en quantité efficace, de manière à traiter cette infection microbienne, ou bien la production endogène de ces peptides EP2 peut être optimisée jusqu'à une quantité efficace pour traiter l'infection microbienne. Ces peptides EP2 sont utiles en tant qu'agents microbiens chez les animaux, y compris les humains, et en tant qu'agents antimicrobiens dans des applications agricoles et industrielles.

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