Mixing apparatus and method

B - Operations – Transporting – 01 – F

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Details

B01F 9/04 (2006.01) B01F 11/00 (2006.01) B01F 13/00 (2006.01) B01F 15/00 (2006.01) G01N 33/15 (2006.01) G01N 1/38 (2006.01) G01N 21/25 (2006.01)

Patent

CA 2399227

Mixing of components, e.g. pharmaceutical actives and excipients, is carried out while monitoring the spectroscopic profile of the mixture during the mixing process so that the spectroscopic profile may be used to determine the point at which mixing is terminated. In one embodiment of the invention, the spectroscopic data is collected by means of a monitoring unit mounted on the mixing vessel. the mixing vessel being mounted and driven so as to rotate or oscillate mounted and thereby effect mixing of its contents and the monitoring unit being mounted for rotation or oscillation with the vessel. When the spectroscopic data indicates that mixing has progressed to a desired state, e.g. the production of a homogeneous blend, the monitoring unit transmits a signal to the drive source to terminate rotation or oscillation of the vessel.

L'invention concerne un mélange de constituants, par exemple des substances pharmaceutiques actives et des excipients, qu'on réalise en même temps qu'on contrôle le profil spectroscopique du processus de mélange, afin d'utiliser ce profil pour déterminer le point d'achèvement du mélange. Dans une forme de réalisation, les données spectroscopiques sont recueillies au moyen d'un dispositif de contrôle monté sur la cuve de mélange, laquelle est montée et entraînée de manière à tourner ou osciller pour effectuer le mélange. Le dispositif de contrôle est monté pour tourner ou osciller avec la cuve. Lorsque les données spectroscopiques indiquent que le déroulement du mélange a atteint un état désiré (par exemple la production d'un mélange homogène), le dispositif de contrôle transmet un signal à une source de commande qui arrête la roation ou l'oscillation de la cuve.

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