A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/198 (2006.01) A61L 12/14 (2006.01) A61P 27/00 (2006.01)
Patent
CA 2545962
The use of organic buffers to enhance the antimicrobial activity of aqueous pharmaceutical compositions is described. The buffers have tri-hydroxy functional groups and terminal acid groups, and are zwitterionic at physiological pH conditions. The most preferred buffer is tricine. The invention is particularly directed to the use of tricine to enhance the antimicrobial activity of ophthalmic compositions, such as solutions for disinfecting contact lenses and artificial tear compositions.
Cette invention concerne des tampons organiques permettant d'améliorer l'activité antimicrobienne de compositions pharmaceutiques aqueuses. Ces tampons comprennent des groupements fonctionnels tri-hydroxy et des groupements acides terminaux, et ils sont zwitterioniques dans des conditions de pH physiologique. Le tampon privilégié dans cette invention est la tricine. Le mode de réalisation décrit dans cette invention concerne plus particulièrement l'utilisation de la tricine pour améliorer l'activité antimicrobienne de compositions ophtalmiques, tels que des solutions permettant de désinfecter des lentilles de contact et des compositions de larmes artificielles.
Dassanayake Nissanke L.
Ketelson Howard Allen
Meadows David L.
Alcon Inc.
Smart & Biggar
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