C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/551 (2006.01) A61P 25/20 (2006.01)
Patent
CA 2688776
The present invention is directed to oxo bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin recep-tors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
La présente invention porte sur des composés de diazépam à pont oxo qui sont des antagonistes des récepteurs de l'oréxine et qui sont utiles dans le traitement ou la prévention de troubles et de maladies neurologiques et psychiatriques dans lesquels les récepteurs de l'oréxine sont mis en jeu. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement de telles maladies dans lesquelles les récepteurs de l'oréxine sont mis en jeu.
Cox Christopher D.
Whitman David B.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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