Anti-pd-l1 antibodies and their use to enhance t-cell function

Details Anti-pd-l1 antibodies and their use to enhance t-cell function Anti-pd-l1 antibodies and their use to enhance t-cell function

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2740806

The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dys-functional disorders, including infection (e.g., acute and chronic) and tumor immunity.

La présente invention concerne des anticorps anti-PD-L1, un acide nucléique les codant, leurs compositions thérapeutiques et leur utilisation pour améliorer la fonction des lymphocytes T en vue de réguler positivement les réponses immunitaires à médiation cellulaire et pour le traitement de troubles dysfonctionnels des lymphocytes T, y compris une infection (par ex. aiguë et chronique) et l'immunité tumorale.

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