Removal of prions from blood, plasma and other liquids

Details Removal of prions from blood, plasma and other liquids Removal of prions from blood, plasma and other liquids

C - Chemistry, Metallurgy

07

K

C07K 1/32 (2006.01) A61K 35/14 (2006.01) A61L 2/00 (2006.01) A61L 2/16 (2006.01) A61L 2/23 (2006.01) A61M 1/34 (2006.01) B01D 15/00 (2006.01) B01D 43/00 (2006.01) B03C 1/00 (2006.01) B03C 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2363846

Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a substrate is coated with a prion complexing agent, such as a metal salt (e.g. sodium) of phosphotungstic acid. Blood or plasma passing through a column containing beads coated with prion complexing agent are rendered prion free. The beads may be comprised of a ferromagnetic core to facilitate removal of the beads from the sample.

Cette invention se rapporte à des dispositifs tels que des colonnes à flux traversant, à des substrats tels que des perles polymères sphériques et à des procédés d'utilisation de ceux-ci pour éliminer les prions de n'importe quel échantillon liquide. A cet effet, une surface d'un substrat est recouverte d'un agent formant complexe avec les prions, tel qu'un sel métallique (par exemple sodium) d'acide phosphotungstique. Le sang ou le plasma traversant une colonne contenant de telles perles recouvertes de l'agent formant complexe avec les prions sont ainsi rendus exempts de tout prion. Lesdites perles peuvent être constituées par un noyau ferromagnétique visant à faciliter l'élimination des perles de l'échantillon.

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