Methods for treating pain and screening analgesic compounds

Details Methods for treating pain and screening analgesic compounds Methods for treating pain and screening analgesic compounds

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61P 29/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2657532

The present invention relates to the use of compounds that block the .alpha.9.alpha.10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the .alpha.9.alpha.10 subtype of the nAChR.

La présente invention concerne l'utilisation de composés qui bloquent le sous-type .alpha.9.alpha.10 du récepteur nicotinique de l'acétylcholine (nAChR) pour traiter la douleur, notamment les douleurs neuropathiques, les douleurs inflammatoires, les troubles inflammatoires tels que l'arthrite. L'invention concerne également des composés de recherche systématique permettant d'identifier des analgésiques qui bloquent le sous-type .alpha.9.alpha.10 du nAChR.

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