Triazole derivatives which are smo antagonists

Details Triazole derivatives which are smo antagonists Triazole derivatives which are smo antagonists

A - Human Necessities

61

K

A61K 31/4245 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2683946

The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: or a pharmaceutically acceptable salt or solvate thereof; wherein: 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom; R1 and R2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R3 represents hydrogen or a fluorine atom; or R1 represents methyl, R2 represents methyl or a fluorine atom and R3 represents a fluorine atom.

La présente invention porte un procédé pour le traitement ou la prévention de conditions qui peuvent être améliorées par un antagonisme de Smo. Ce procédé comprend l'administration à un patient en ayant besoin d'une quantité efficace d'un composé de formule I ou d'une composition comprenant un composé de formule I: ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci; où: 2 parmi X, Y et Z représentent des atomes d'azote, et l'autre représente un atome d'oxygène; R1 et R2 sont pris ensemble avec l'atome auquel ils sont attachés et représentent un noyau cyclobutyle, facultativement substitué par 1-2 atomes de fluor, et R3 représente hydrogène ou un atome de fluor; ou R1 représente méthyle, R2 représente méthyle ou un atome de fluor et R3 représente un atome de fluor.

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