Methods and formulations for protecting cells, and for...

Details Methods and formulations for protecting cells, and for... Methods and formulations for protecting cells, and for...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 8/49 (2006.01) A61K 8/55 (2006.01) A61K 8/60 (2006.01) A61K 8/64 (2006.01) A61K 31/455 (2006.01) A61K 31/7024 (2006.01) A61K 38/18 (2006.01) A61P 9/00 (2006.01) A61Q 19/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2553542

Pharmaceutical and cosmetic formulations and methods for optimizing the intracellular concentrations of NAD are provided. The present methods and compounds relate to the use of PBEF, PRPP and various forms of nicotinamide, individually or in combination, for therapeutic, cyto-protective, cosmetic and anti-aging purposes. PBEF, PRPP and nicotinamide, individually or in combination, as administered according to the invention, increase the metabolic fitness, health and performance of the cell, and thereby increase the cell's level of health during its lifecycle. By way of the present formulations and methods, optimizing the intracellular concentration of NAD+ facilitates a balance among the numerous intracellular interactions of NAD+, and its related pathways, such that the health of the cell and its resistance to stress and trauma are increased. This increased robustness attendant to the invention also facilitates the delay of apoptosis.

L'invention concerne des préparations pharmaceutiques et cosmétiques et des méthodes destinées à l'optimisation des concentrations intracellulaires du NAD. Les méthodes et les composés de la présente invention sont liés à l'utilisation du facteur de stimulation de la colonie de cellules Pré-B (PBEF), au 5-phosphoriboxyl-pyrophosphate (PRPP) et à diverses formes de nicotinamide, seuls ou combinés, à des fins thérapeutiques, cytoprotectrices, cosmétiques et anti-vieillissement. Le PBEF, le PRPP et le nicotinamide, seuls ou combinés, lorsqu'ils sont administrés selon les méthodes de l'invention, permettent d'améliorer la santé métabolique, la santé et les performances des cellules, et, par conséquent, d'améliorer l'état de santé général des cellules durant leur cycle de vie. Les présentes préparations et méthodes permettent d'optimiser la concentration intracellulaire du NAD<SUP>+</SUP> et, par conséquent, d'obtenir un meilleur équilibre entre les nombreuses interactions intracellulaires du NAD<SUP>+</SUP> et ses voies associées, et ainsi d'améliorer l'état de santé des cellules et d'augmenter leur résistance au stress et aux traumatismes. Cette robustesse accrue retarde également l'apoptose.

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