Thiophene and thiazole substituted trifluoroethanone...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/04 (2006.01) A61K 31/381 (2006.01) A61K 31/4245 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2641933

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, 10 schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.

La présente invention a pour objet des composés de formule I, ainsi que des sels et des tautomères de qualité pharmaceutique desdits composés. Les composés selon la présente invention sont des inhibiteurs de l'histone désacétylase (HDAC) et peuvent être employés dans le traitement de maladies de prolifération cellulaire, y compris le cancer. Ils peuvent également être employés dans le traitement de maladies neurodégénératives, des retards mentaux, de la schizophrénie, de maladies inflammatoires, de la resténose, des troubles immuns, du diabète, des troubles cardio-vasculaires et de l'asthme.

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