Novel sulfonyloxazolamines

Details Novel sulfonyloxazolamines Novel sulfonyloxazolamines

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/422 (2006.01) A61P 25/00 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 263/48 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2389679

The invention relates to compounds of the general formula (I), wherein R1 and R2 independently of one another represent H, -R6, C3-C8-cycloalkyl, -(CH2)n- R7, -(CH2)n-O-R6, -(CH2)n-NH2, -(CH2)n-NHR6, -(CH2)-N(R6)2, C2-C6-alkenyl or optionally together form a mononuclear saturated heterocycle with one or two nitrogen, oxygen and/or sulphur atoms; R3 and R4 independently of one another represent H, -R6, -CF3, -NO2, -Hal, -OH, -O-R6, -NH2, -NH-R6, or -N(R6)2; R5 represents a 5- or 6-member, saturated or unsaturated heterocycle with one or two nitrogen, oxygen and/or sulphur atoms, which is optionally monosubstituted or disubstituted by -R6, -CF3, -NO2, -Hal, -OH, -O-R6, -NH2, -NH-R6, or - N(R6)2; and R6 represents C1-C6-alkyl; R7 together with R3 and/or R4 represents substituted phenyl, n represents 0 to 2. The invention also relates to the physiologically safe salts or solvates of said compounds and to the use of the compounds of the general formula (I) as medicaments.

L'invention concerne des composés de la formule générale (I) ainsi que leurs sels ou solvats acceptables sur le plan physiologique. Dans ladite formule (I), R¿1? et R¿2? représentent indépendamment l'un de l'autre H, -R¿6?, cycloalkyle C¿3?-C¿8?, -(CH¿2?)¿n?-R¿7?, -(CH¿2?)¿n?-O-R¿6?, -(CH¿2?)¿n?-NH¿2?, -(CH¿2?)¿n?-NHR¿6?, -(CH¿2?)-N(R¿6?)¿2?, alcényle C¿2?-C¿6? ou éventuellement forment ensemble un hétérocycle saturé ayant un noyau avec un ou deux atomes d'azote, d'hydrogène et/ou de soufre; R¿3? et R¿4? représentent indépendamment l'un de l'autre H, -R¿6?, -CF¿3?, -NO¿2?, -Hal, -OH, -O-R¿6?, -NH¿2?, -NH-R¿6?, ou -N(R¿6?)¿2?; R¿5? représente un hétérocycle saturé ou insaturé à 5 ou 6 chaînons avec un ou deux atomes d'azote, d'hydrogène et/ou de soufre, hétérocycle éventuellement monosubstitué ou disubstitué par -R¿6?, -CF¿3?, -NO¿2?, -Hal, -OH, -O-R¿6?, -NH¿2?, -NH-R¿6?, ou -N(R¿6?)¿2?; R¿6? représente alkyle C¿1?-C¿6?, R¿7? avec R¿3? et/ou R¿4? représente phényle substitué ; et n représente 0 à 2. La présente invention concerne également l'utilisation des composés de la formule générale (I) comme médicaments.

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