Compositions and methods for the delivery of nitric oxide

Details Compositions and methods for the delivery of nitric oxide Compositions and methods for the delivery of nitric oxide

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/42 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) C07K 14/195 (2006.01) C07K 14/435 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12P 21/02 (2006.01) A61K 33/00 (2006.01)

Patent

CA 2653101

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.

L'invention concerne des protéines H-NOX qui sont mutées pour obtenir des propriétés de cinétique et de thermodynamique de libération de NO gazeux dans le sang améliorées ou optimales. Les protéines H-NOX modifiées comprennent des mutations qui entraînent une modification de la liaison de NO ou de O2 avec le ligand, par rapport au domaine H-NOX de type sauvage correspondant, et peuvent être employés en tant que vecteurs sanguins de NO gazeux physiologiquement compatibles chez les mammifères. La présente invention concerne également des compositions pharmaceutiques, des kits et des méthodes utilisant les protéines H-NOX sauvages ou mutantes dans le traitement de tout état pathologique dans lequel la libération de NO est avantageuse.

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