C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12P 15/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2299630
A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.
L'invention concerne un produit de transcription unique, CRCA-1, et des produits de traduction variés issus de ce dernier. Le transcrit et ses produits de traduction sont des marqueurs pour les cellules colorectales. L'invention concerne également des réactifs de criblage et de diagnostic, des ensembles et des méthodes pour les cancers colorectaux métastasés ainsi que des réactifs, des ensembles et des techniques permettant de déterminer l'origine colorectale des adénocarcinomes. L'invention concerne en outre des composés, compositions et méthodes permettant de traiter les patients présentant un cancer colorectal métastasé et de visualiser les tumeurs colorectales métastasées in vivo, ainsi que des compositions et des méthodes permettant de distribuer des composés actifs tels que des traitements géniques et des composés antisens dans les cellules colorectales. L'invention concerne enfin des compositions et des méthodes de traitement et de prévention du cancer colorectal métastasé.
Barber Michael T.
Parkinson Scott J.
Pearlman Joshua M.
Schulz Stephanie
Waldman Scott A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Thomas Jefferson University
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