Pyrimidine derivatives for the prevention of hiv infection

Details Pyrimidine derivatives for the prevention of hiv infection Pyrimidine derivatives for the prevention of hiv infection

C - Chemistry, Metallurgy

07

D

C07D 239/47 (2006.01) A61K 31/505 (2006.01) A61P 31/18 (2006.01) C07D 239/46 (2006.01)

Patent

CA 2513527

This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; and pharmaceutical compositions comprising them.

Cette invention se rapporte à l'utilisation d'un composé servant à fabriquer un médicament utilisé dans la prévention des infections par le VIH transmises à la suite de rapports sexuels ou de contacts intimes apparentés entre partenaires. Ce composé est un composé représenté par la formule (I), un <i>N</i>-oxyde, un sel d'addition pharmaceutiquement acceptable, une amine quaternaire et une forme stéréochimiquement isomère de ce composé, formule dans laquelle le cycle contenant -a?1¿=a?2¿-a?3¿=a?4¿- et -b?1¿=b?2¿-b?3¿=b?4¿- représente phényle, pyridyle, pyrimidinyle, pirazinyle, pyridazinyle; cette invention concernant également des compositions pharmaceutiques comprenant ce composé et ses dérivés.

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