Therapeutic agent for keratoconjunctival disorder

Details Therapeutic agent for keratoconjunctival disorder Therapeutic agent for keratoconjunctival disorder

A - Human Necessities

61

K

A61K 31/421 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 31/517 (2006.01) A61P 27/02 (2006.01) C07D 263/32 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2543555

New medicinal uses of 5-[4-[[3-methyl-4-oxo-3,4-dihydro-2- quinazolinyl]methoxy]~phenylmethyl]thiazolidine-2,4-dione and N-[(4- methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4- oxazolyl)ethoxy]phenyl]methyl]glycine. The compounds each has an excellent ameliorative effect on corneal disorder models and is useful in treatments for keratoconjunctiva disorders such as dry eye, corneal ulcer, corneitis, conjunctivitis, superficial punctate keratopathy, subepithelial corneal defects, subepithelial conjunctival defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, and filamentous keratitis.

L'invention concerne de nouvelles utilisations médicales de 5-[4-[[3-méthyl-4-oxo-3,4-dihydro-2-quinazolinyl]méthoxy]-phénylméthyl]thiazolidino-2,4-dione et de N-[(4-méthoxyphénoxy)carbonyl]-N-[[4-[2-(5-méthyl-2-phényl-4-oxazolyl)éthoxy]phényl]méthyl]glycine. Chacun de ces composés présente un excellent effet d'amélioration de modèles de troubles cornéens et s'avère utile dans des traitements de troubles de kérato-conjonctivite tels que la sécheresse occulaire, l'ulcère cornéen, la cornéite, la conjonctivite, la kératopathie ponctuée superficielle, les défauts cornéens sous-épithéliaux, les défauts conjonctivaux sous-épithéliaux, la kératoconjonctivite sèche, la kératoconjonctivite limbique supérieure et la kératite filamenteuse.

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