Thrombin preparations and process for their production

Details Thrombin preparations and process for their production Thrombin preparations and process for their production

C - Chemistry, Metallurgy

12

N

C12N 9/74 (2006.01) A61K 38/48 (2006.01) A61K 47/18 (2006.01) A61L 24/10 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2735316

The production of a thrombin preparation which is obtained from prothrombin which is, after activation to thrombin without the addition of thromboplastin, purified by a hydrophobic interaction chromatography, it being possible subsequently also to inactivate or remove viruses, is described. Before or after the hydrophobic interaction chromatography it is also possible in addition to carry out a cation exchange chromatography. A thrombin preparation which contains as stabilizer a noncovalently binding inhibitor and to which further stabilizers can be added for stabilization in the liquid state is additionally described.

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