Imidazole derivatives with biphenylsulfonyl substitution,...

Details Imidazole derivatives with biphenylsulfonyl substitution,... Imidazole derivatives with biphenylsulfonyl substitution,...

C - Chemistry, Metallurgy

07

D

C07D 233/70 (2006.01) A61K 31/4164 (2006.01) C07D 233/88 (2006.01)

Patent

CA 2338059

The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.

Des composés de la formule (I), dans laquelle les symboles ont la signification indiquée dans les revendications, possèdent de remarquables propriétés anti-arythmiques et comportent un constituant cardioprotecteur. Ils peuvent préventivement inhiber ou réduire fortement les processus pathophysiologiques lors de l'apparition de lésions d'origine ischémique, notamment lors du déclenchement d'arythmies cardiaques d'origine ischémique. Ils présentent en outre un puissant effet inhibiteur sur la prolifération cellulaire.

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