A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61P 3/00 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2644046
The present invention relates to metabolic regulators that affect metabolic function, for example metabolic regulators that affect muscle mass, muscle regeneration, muscle hypertrophy, fat mass, insulin and glucose sensitivity, angiogenesis and cardiovascular function. In particular, the present invention relates to modulating metabolic function by administering an effective amount of a pharmaceutical composition comprising an agent, where the agent activates or inhibits the activity and/or gene expression of the metabolic regulator. The metabolic regulators of the present invention are, for example MSPl (2160028F08Rik; SEQ ID NO: 16); MSP2 (2310043I08Rik; SEQ ID NO: 17); MSP3 (NM_026754;l 110017116Rik;SEQ ID NO: 1); MSP4 (4732466D17Rik; SEQ BD NO:18); MSP 5 (NM_024237; 1600015H20Rik; SEQ ID NO:12); Insl6 (AF_156094; SEQ ID NO:20). The present invention also provides methods to screen for agents that affect the metabolic regulators of the present invention.
L'invention concerne des régulateurs métaboliques qui affectent la fonction métabolique, tels que ceux qui affectent la masse musculaire, la régénération musculaire, l'hypertrophie musculaire, la masse adipeuse, l'insuline et la sensibilité au glucose, l'angiogenèse et la fonction cardiovasculaire. Plus précisément, l'invention concerne la modulation de la fonction métabolique par administration d'une dose efficace d'une composition pharmaceutique comprenant un agent qui active ou inhibe l'activité et/ou l'expression génique du régulateur métabolique. Les régulateurs métaboliques selon l'invention sont, par exemple, MSPl (2160028F08Rik; SEQ ID NO: 16); MSP2 (2310043I08Rik; SEQ ID NO: 17); MSP3 (NM_026754;l 110017116Rik;SEQ ID NO: 1); MSP4 (4732466D17Rik; SEQ BD NO:18); MSP 5 (NM_024237; 1600015H20Rik; SEQ ID NO:12); Insl6 (AF_156094; SEQ ID NO:20). L'invention concerne enfin des procédés permettant de cribler les agents qui affectent lesdits régulateurs métaboliques.
Ouchi Noriyuki
Walsh Kenneth
Zeng Ling
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Trustees Of Boston University
LandOfFree
Metabolic regulators and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Metabolic regulators and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metabolic regulators and uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1595026