C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 38/27 (2006.01) C07K 14/47 (2006.01) C07K 14/48 (2006.01) C07K 14/61 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2343651
The invention relates to the use of SOCS-2 and/or CIS, purified or recombinant, to screen for compounds enhancing the effect of growth hormone; assay systems and methods to screen for compounds that reduce the level of SOCS-2 and/or CIS comprising cultured cells in which levels of SOCS-2 and/or CIS can be monitored; to screen for compounds that reduce the biological activity of SOCS-2 and/or CIS comprising purified or recombinant SOCS-2 and/or CIS and proteins that link SOCS-2 and/or CIS to signaling molecules dependent on GH; a method to increase cellular sensitivity to GH by a reduction of the levels of SOCS-2 and/or CIS.
L'invention concerne l'utilisation de protéines SOCS-2 et/ou CIS, purifiées ou recombinées, pour cribler des composés renforçant l'effet de l'hormone de croissance; des systèmes et des procédés de criblage de composés qui réduisent le taux de SOCS-2 et/ou de CIS, comprenant des cellules cultivées dans lesquelles les taux de SOCS-2 et/ou de CIS peuvent être surveillés; des systèmes et des procédés de criblage de composés qui réduisent l'activité biologique de SOCS-2 et/ou de CIS, comprenant des protéines SOCS-2 et/ou CIS purifiées ou recombinées qui se lient à des molécules de signalisation de SOCS-2 et/ou de CIS dépendant de l'hormone de croissance; un procédé permettant d'augmenter la sensibilité cellulaire à l'hormone de croissance par une réduction des taux de SOCS-2 et/ou de CIS.
Flores Morales Amilcar
Norstedt Gunnar
Tollet Egnell Petra
Sahltech I. Goteborg Ab
Smart & Biggar
LandOfFree
Use of socs-2 or cis to screen for compounds enhancing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of socs-2 or cis to screen for compounds enhancing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of socs-2 or cis to screen for compounds enhancing... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1595122