Reconstructing organs from decellularized biomaterial scaffold

Details Reconstructing organs from decellularized biomaterial scaffold Reconstructing organs from decellularized biomaterial scaffold

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 35/23 (2006.01) A61L 27/38 (2006.01) A61M 1/14 (2006.01) C12N 5/00 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2395698

The invention is directed to compositions and methods for reconstructing an artificial organ. The artificial organ is reconstructed using a three-dimensional scaffold produced by decellularizing biostructures from a donor organ. The three-dimen-sional scaffold is perfused with endothelial cells that develop to produce an endothelial tissue layer with a primitive vascular system that sustains the growth and development of a second cultured cell population. When grown in the three-dimensional scaffold and endothelial tissue layer, with the primitive vascular system, the cells of the second cell population proliferate, mature and differentiate into neomorphic organ structures that are analogous to their in vivo counterparts.

L'invention concerne des compositions et des méthodes de reconstruction d'un organe artificiel. L'organe artificiel est reconstruit à l'aide d'une greffe tridimensionnelle produite par la décellularisation de biostructures d'un organe donneur. La greffe tridimensionnelle est perfusée avec des cellules endothéliales qui se développent pour produire une couche tissulaire endothéliale avec un système vasculaire primitif qui soutient la croissance et le développement d'une seconde population cellulaire cultivée. Lorsqu'elles se développent dans la greffe tridimensionnelle et la couche tissulaire endothéliale, avec le système vasculaire primitif, les cellules de la seconde population cellulaire prolifèrent, arrivent à maturité et se différencient en structures organiques néomorphiques qui sont analogues à leurs homologues <i>in vivo</i>.

Affiliated with

Also associated with

Rating

Reconstructing organs from decellularized biomaterial scaffold does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reconstructing organs from decellularized biomaterial scaffold, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reconstructing organs from decellularized biomaterial scaffold will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1595260