Novel nucleic acid and polypeptide with homology to the...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2316545

The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated NTR-5. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the MAMMALIAN NTR-5 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between MAMMALIAN NTR-5 and agents that initiate signal transduction through binding to MAMMALIAN NTR-5. In a specific embodiment, the MAMMALIAN NTR-5 may HUMAN NTR-5 or MOUSE NTR-5.

La présente invention porte sur des séquences d'acide nucléique codant de nouveaux polypeptides récepteurs mammaliens appelés NTR-5. Cette invention porte également sur des systèmes de dosage pouvant être utilisés pour détecter et/ou mesurer des ligands qui fixent le produit génique mammalien NTR-5, ainsi que sur des méthodes diagnostiques et thérapeutiques basées sur l'interaction entre NTR-5 mammalien et des agents qui déclenchent la transduction du signal par fixation sur NTR-5. Selon une réalisation spécifique, NTR-5 mammalien peut être un NTR-5 humain ou de souris.

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