C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2486339
(Formula I). Substituted ring-fused imidazole derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptorsin vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent (s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).
L'invention porte sur des dérivés d'imidazole à cycles fusionnés se fixant aux récepteurs GABA<SB>A</SB>. Lesdits composés peuvent servir à moduler les ligands se fixant aux récepteurs GABA<SB>A </SB><i>in vivo</i> ou <i>in vitro</i>, et sont particulièrement utiles dans le traitement de différents troubles du SNC chez l'homme et les animaux domestiques ou d'élevage. L'invention porte également sur des préparations pharmaceutiques et des procédés de traitement desdits troubles, et sur des procédés d'utilisation desdits ligands pour détecter les récepteurs GABA<SB>A </SB>(par exemple dans des études de localisation de récepteurs).
Currie Kevin
Luke George P.
Maynard George D.
Yuan Jun
Neurogen Corporation
Osler Hoskin & Harcourt Llp
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