Use of steroidal alkaloids to reverse multidrug resistance

Details Use of steroidal alkaloids to reverse multidrug resistance Use of steroidal alkaloids to reverse multidrug resistance

A - Human Necessities

61

K

A61K 31/58 (2006.01) A61K 45/06 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2395642

The invention provides steroidal alkaloids for inhibiting or reversing multidrug resistance in cancer or in bacterial, fungal or parasitic infections. The steroidal alkaloid may be administered to the patient alone or in combination with an anticancer, antibacterial, antifungal or antiparasitic agent. Examples of steroidal alkaloids include members of the solanidane or spirosolane e.g. tomatidine, families, and C-nor-D-homo steroid such as of the jervane or veratramine families.

L'invention concerne des alcaloïdes stéroïdiques destinés à inhiber ou à neutraliser la résistance à l'action de plusieurs médicaments dans le traitement de cancers ou d'infections bactériennes, fongiques ou parasitaires. L'alcaloïde stéroïdique peut être administré au patient, seul ou en combinaison avec un agent anticancéreux, antibactérien, antifongique ou antiparasitaire. Des exemples d'alcaloïdes stéroïdiques comprennent des membres des familles solanidane ou spirosolane, c.-à-d. de tomatidine, et des stéroïdes C-nor-D-homo tels que ceux des familles jervane ou veratramine.

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