Opioid formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4468 (2006.01) A61K 31/4535 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2402865

The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000- fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long- term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.

La présente invention concerne des formulations à teneur élevée en opioïdes, notamment le fentanyl ou les congénères de fentanyl. La formulation de cette invention contient du fentanyl ou un congénère de fentanyl dans des proportions particulièrement élevées par rapport aux formulations classiques, par exemple, dans l'ordre d'environ 2 fois à environ 10 000 supérieures aux formulations classiques, notamment, les formulations actuellement disponibles dans le commerce. Ces formulations sont particulièrement utiles dans le cadre d'une administration à long terme à un sujet souffrant de douleur. En outre, cette invention concerne des dispositifs d'administration de médicaments renfermant ces formulations à teneur élevée en opioïdes, et concerne également des méthodes permettant d'atténuer la douleur chez un sujet, consistant à lui administrer ces formulations à teneur élevée en opioïdes.

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