Process for production of polypeptide by regulation of assembly

Details Process for production of polypeptide by regulation of assembly Process for production of polypeptide by regulation of assembly

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2603408

It is found that the assembly of polypeptides can be inhibited by altering an amino acid residue that forms the interface between the polypeptides in the assembly into another amino acid residue having the same charge as that of the amino acid residue. Thus, it becomes possible to form a hetero molecule with good efficiency. The present process can be suitably used, for example, in the production of a bispecific antibody.

On découvre que l~ensemble de polypeptides peut être inhibé en altérant un résidu d~acide aminé qui forme l~interface entre les polypeptides de l~ensemble en un autre résidu d~acide aminé ayant la même charge que le premier résidu d~acide aminé. Ainsi, il devient possible de former une hétéro molécule avec un bon rendement. Le présent procédé peut être utilisé de façon adéquate, par exemple, dans la production d~un anticorps bispécifique.

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