Anthrax lethal factor is a mapk kinase protease

Details Anthrax lethal factor is a mapk kinase protease Anthrax lethal factor is a mapk kinase protease

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2324379

The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.

La présente invention concerne des procédés permettant de rechercher systématiquement, in vitro comme ex vivo, des modulateurs, des homologues et des mimétiques de l'activité protéasique de la MAPKK (mitogen activated protein kinase kinase) du facteur létal, c'est-à-dire la kinase de protéine kinase activée par les mitonnes du facteur létal. L'invention concerne également une thérapie anticancéreuse consistant en l'administration de facteur létal à des cellules transformées.

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