Diamino phenothiazine derivatives and composition comprising...

C - Chemistry – Metallurgy – 07 – D

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C07D 279/18 (2006.01) A61K 31/5415 (2006.01) A61P 31/00 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2410824

The invention concerns a diamino phenothiazine derivative, at least monosubstituted in one of its positions 1, 2, 3, 4, 5, 6, 7 or 8 and having a quinone para and ortho tautomerism, of general formula (I) or one of its salts, wherein: R1, R2, R4, R5, R6, R7, R8 and R1', R2', R3', R4' are identical or different from one another and represent: a hydrogen atom, an aliphatic and/or aromatic and/or cyclic radical, such as an alkyl group, an alkenyl group, an alkynyl group, a hydroxy group, an aryloxy group, a ketone group, an amide group, a carboxy group, a base, a non-organic radical such as a halogen atom, an alkaline-earth, a metal atom; and X is a mineral or organic anion, except for blue A, blue B, blue C, methylene green, novel methylene blue, toluidine blue derivatives. The invention is applicable in the biological and/or chemical field.

L'invention concerne un dérivé de diamino phénothiazine, au moins monosubstitué en l'une des positions 1, 2, 3, 4, 5, 6, 7 ou 8 et présentant une tautomérie para et ortho quinonique, de la formule générale (I) ou l'un de ses sels, dans laquelle: R1, R2, R4, R5, R6, R7, R8 et R1', R2', R3', R4' sont identiques ou différents l'un de l'autre et représentent: un atome d'hydrogène, un radical aliphatique et/ou aromatique et/ou cyclique, tel qu'un groupe alkyle, un groupe alkényle, un groupe alkynyle, un groupe hydroxy, un groupe aryloxy, un groupe cétone, un groupe amide, un groupe carboxy, une base, un radical non organique tels qu'un atome halogène, un alcalino-terreux, un atome métallique; et X est un anion minéral ou organique; à l'exception des dérivés que sont l'azure A, l'azure B, l'azure C, le vert de méthylène, le nouveau bleu de méthylène, le bleu de toluidine. Application au domaine biologique et/ou chimique.

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