Substituted aryl-cycloalkanes, and use thereof as anticancer...

Details Substituted aryl-cycloalkanes, and use thereof as anticancer... Substituted aryl-cycloalkanes, and use thereof as anticancer...

C - Chemistry, Metallurgy

07

C

C07C 49/84 (2006.01) A61K 31/122 (2006.01) A61K 31/136 (2006.01) A61P 35/00 (2006.01) C07C 49/825 (2006.01) C07C 225/22 (2006.01)

Patent

CA 2469349

The invention concerns products of formula (I), wherein: A represents a saturated or partly saturated cyclic hydrocarbon, optionally substituted; X is selected from the group consisting of O, N-O(R2); Ar¿1? represents a substituted phenyl ring; and Ar¿2? is selected from the group consisting of certain substituted phenyl rings or nitrogenous heterocycles. Said products are useful as anticancer agents, in particular as tubulin polymerization inhibitors.

Les produits répondant à la formule (I) dans laquelle: - A représente un hydrocarbure cyclique saturé ou partiellement insaturé, éventuellement substitué, - X est sélectionné dans le groupe constitué par O, N-O-(R2), - Ar1 représente un premier noyau phényle, substitué, et Ar2 est sélectionné dans le groupe constitué par certains noyaux phényles substitués ou hétérocycles azotés, sont utiles comme agents anticancéreux, en particulier comme inhibiteurs de polymérisaion de la tubuline.

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