A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2559658
Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti- Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
L'invention concerne des anticorps anti-Lewis Y. L'invention concerne également des méthodes de préparation de conjugués de supports/médicaments cytotoxiques monomériques présentant une charge médicamenteuse significativement plus élevée que dans l'état antérieur de la technique, ainsi qu'une agrégation réduite et une fraction conjuguée faible (LCF). L'invention concerne en outre des conjugués d'anticorps/dérivés médicamenteux cytotoxiques, des compositions comprenant lesdits conjugués ainsi que des utilisations desdits conjugués. L'invention concerne de manière spécifique des conjugués d'anticorps anti-Lewis Y/dérivés de calichéamicine monomériques, des compositions comprenant lesdits conjugués ainsi que des utilisations desdits conjugués.
Boghaert Erwin Raymond Arsene
Damle Nitin Krishnaji
Hamann Philip Ross
Jain Neera
Kunz Arthur
Smart & Biggar
Wyeth
LandOfFree
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