C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/101, 530/15,
C07F 1/00 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61N 5/10 (2006.01) C07F 15/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2005039
ABSTRACT Pharmaceuticals and Apparatus used in combination for diagnosis and tissue necrosis applicable to provide effective and selective therapy using the Mossbauer absorption phenomenon. Selected pharmaceutical compounds containing a radiation absorber isotope are administered to a tissue and excited by a radiation source (50) which provides energy at the corresponding resonant Mossbauer absorption frequency of isotope containing pharmaceutical, where excitation effects nuclear transitions to cause highly selective energy absorption in the selected target tissue. For diagnostic purposes, de-excitation fluorescence of the isotope is monitored. For therapeutic purposes, the energy is converted to particle radiation by the isotope at the target tissue by internal conversion followed by an Auger election cascade which results in radlolysis of DNA resulting in lethal double strand breaks in the DNA molecules of the target tissue. The tissue selectivity is achieved by providing a Mossbauer absorption frequency of the target tissue which differs from that of surrounding tissue.
French David J.
Mills Randell L.
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