A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2398927
Methods, formulations and kits are described for resuscitating a patient suffering from cardiac arrest, for enhancing the efficacy of cardiopulmonary resuscitation, for treating post-resuscitation hypotension, and for reducing the incidence of ventricular arrhythmias and myocardial dysfunction in a patient following cardiopulmonary resuscitation. Prior methods and agents often cause inotropic or chronotropic effects, which can lead to undesirable post-resuscitation myocardial dysfunction. The invention comprises administering a therapeutically effective amount of an .alpha.2-receptor agonist that does not cross the blood-brain barrier, such as .alpha.- methylnorepinephrine, to enhance cardiopulmonary resuscitation.
L'invention concerne des procédés, des formulations, et des ensembles destinés à réanimer un patient victime d'un arrêt cardiaque, à améliorer l'efficacité de la réanimation cardio-pulmonaire, à traiter l'hypotension post-réanimatoire, et à réduire les risques d'arythmies ventriculaires et de dysfonctionnement myocardiaque après réanimation cardio-pulmonaire. Les procédés et agents antérieurs causent souvent des effets inotropiques ou chronotropiques pouvant entraîner des dysfonctionnements myocardiaques post-réanimatoires gênants. Le procédé selon l'invention consiste à administrer une quantité thérapeutique efficace d'un agoniste de .alpha.¿2?-récepteur ne passant pas la barrière hémato-encéphalique, tel que la .alpha.-méthylnorépinéphrine, afin d'améliorer la réanimation cardio-pulmonaire.
Bisera Jose
Tang Wanchun
Weil Max Harry
Battison Williams Dupuis
Institute Of Critical Care Medicine
LandOfFree
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