C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 9/00 (2006.01) A61K 38/14 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2091024
Abstract of the disclosure 92/B 005-Ma 935 Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds N-Glycopeptide derivatives of the formula I Image formula I where aromatic is an unsubstituted or substituted benzene residue, naphthalene residue, chroman residue, chromene residue or coumarone residue, a is 0 to 5, b is 0 to 4, c is 0 or 1, d is 1 or 2 R1 is (C1-C3)-alkyl, R2 is (C1-C3)-alkyl or (C1-C3)-alkyloxy, R3 is H, OH, (C1-C3)-alkyloxy, NH2, NH-(C1-C6)-alkanoyl, NH-benzoyl, NH-SO3H or NH-acyl radical of a natural N-acetylated amino acid, R4 is H, OH, or (C1-C3)-alkyloxy, R5 is H, OH, (C1-C3)-alkyloxy, fluorine, chlorine or bromine, R6 is H, CH3, CH2OH, CH2O-(C1-C6)-alkanoyl, CH2NHCOCH3 or CH2NH-SO3H, R5 and R6 are together O-CH2-O-CH2, O-CH(CH3)-O-CH2 or O-C(CH3)2-O-CH2, R7 is hydroxy-(C2-C4)-alkyl or (C2-C4)-alkyloxy-(C2-C4)-alkyl, R8 is H or (C1-C6)-alkyl or R7-N-R8 are together a pyrrolidine ring, piperidine ringor morpholine ring, which can be substituted by HO, HOCH2, CH3 or COOH, W -O-, -CONH- or-C6H4-CONH and H-X is HCI, a (C1-C7)-alkanoic acid or another pharmacologically tolerated inorganic or organic acid, are described, as are a process for their preparation and a pharmaceutical agentwhich contains these novel compounds. These pharmaceuticals can be used in particular for the therapy of thrombotic disorders.
Kolar Cenek
Stuber Werner
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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