C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) C12N 15/88 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432350
The invention relates to a method for inhibiting the expression of a target gene in a cell, comprising the following steps: introduction of an amount of at least one dual-stranded ribonucleic acid (dsRNA I) which is sufficient to inhibit the expression of the target gene. The dsRNA I has a dual-stranded structure formed by a maximum of 49 successive nucleotide pairs. One strand (as1) or at least one section of the one strand (as1) of the dual-stranded structure is complementary to the sense strand of the target gene. The dsRNA has an overhang on the end (E1) of dsRNA I formed by 1 - 4 nucleotides.
L'invention concerne un procédé permettant d'inhiber l'expression d'un gène cible dans une cellule. Ce procédé consiste à introduire au moins un acide ribonucléique double brin (dsRNA I) dans une quantité suffisante pour inhiber l'expression du gène cible. Le dsRNA I présente une structure double brin formée de 49 paires successives de nucléotides au maximum. Un brin (as1) ou au moins une partie d'un brin (as1) de cette structure double brin est complémentaire du brin sens du gène cible. Le dsRNA présente à une extrémité (E1) du dsRNA I une partie en saillie formée de 1 à 4 nucléotides.
Hadwiger Philipp
Kreutzer Roland
Limmer Stephan
Rost Sylvia
Fetherstonhaugh & Co.
Ribopharma Ag
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