Umlr polypeptides

Details Umlr polypeptides Umlr polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2391820

Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonist. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.

L'invention concerne de nouveaux polypeptides du récepteur du facteur de nécrose tumorale (TNFR) secrétés et membranaires, des polynucléotides les codant, des anticorps, ainsi que des compositions et des procédés connexes. Les polypeptides peuvent être utilisés pour détecter des ligands, des agonistes et des antagonistes. Les polypeptides, polynucléotides et anticorps peuvent également être utilisés dans des procédés qui modulent l'inflammation, la croissance tumorale et les métastases, l'infection, l'immunité et la maturation cellulaire.

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