Lactic acid bacteria-derived double-stranded rna

Details Lactic acid bacteria-derived double-stranded rna Lactic acid bacteria-derived double-stranded rna

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/713 (2006.01) A61K 35/74 (2006.01) A61P 37/02 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2694354

An immunoregulator that is safe and efficiently incorporated into cells along with a production process thereof are provided. Double-stranded RNA derived from lactic acid bacteria, an immunoregulator having for an active ingredient thereof double-stranded RNA derived from lactic acid bacteria, and a process for producing double-stranded RNA derived from lactic acid bacteria are provided. Bacteria cells of a strains of lactic acid bacteria such as genus Tetragenococcus, genus Pediococcus, genus Lactobacillus, genus Streptococcus or genus Leuconostoc are able to produce double-stranded RNA having immunoregulatory action therein.

L'invention concerne un immunomodulateur, qui a une sûreté élevée et peut être effectivement incorporé dans des cellules, et son procédé de production. L'invention concerne également un ARN double brin provenant d'une bactérie d'acide lactique ; un immunomodulateur comprenant l'ARN double brin provenant d'une bactérie d'acide lactique en tant qu'ingrédient actif ; et un procédé de production d'ARN double brin provenant d'une bactérie d'acide lactique. Des cellules bactériennes d'acide lactique appartenant au genre Tetragenococcus, Pediococcus, Lactobacillus, Streptococcus, Leuconostoc, etc. peuvent produire un ARN double brin contenant un effet d'immunomodulation.

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