Chemical synthesis of a highly potent epothilone

Details Chemical synthesis of a highly potent epothilone Chemical synthesis of a highly potent epothilone

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/428 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2628227

A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.

La présente invention a trait à un composé à base d'épothilone de synthèse très actif dont l'activité est supérieure à celle de l'EpoA ou l'EpoB lorsqu'il est soumis à un dosage sous la forme d'un agent cytotoxique contre une lignée cellulaire cancéreuse ainsi qu'à une composition pharmaceutique contenant l'épothilone de synthèse.

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