Slc2as as modifiers of the p53 pathway and methods of use

Details Slc2as as modifiers of the p53 pathway and methods of use Slc2as as modifiers of the p53 pathway and methods of use

A - Human Necessities

61

K

A61K 48/00 (2006.01) A01N 63/00 (2006.01) A61K 49/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449425

Human SLC2A genes are identified as modulators of the p53 pathway, and thus as therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SLC2A are provided.

Des gènes SLC2A humains on été identifiés comme des modulateurs de la voie p53, et sont donc des cibles thérapeutiques destinées à des troubles associés à une fonction p53 déficiente. L'invention concerne des procédés d'identification de modulateurs de p53, consistant à effectuer le criblage d'agents qui modulent l'activité de SLC2A.

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