Glucocorticoid mimetics, methods of making them,...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/10 (2006.01) C07D 209/42 (2006.01) C07D 211/04 (2006.01) C07D 215/06 (2006.01) C07D 215/227 (2006.01) C07D 215/233 (2006.01) C07D 217/04 (2006.01) C07D 217/24 (2006.01) C07D 231/12 (2006.01) C07D 235/06 (2006.01) C07D 295/13 (2006.01) C07D 307/79 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2694224

Compounds of Formula (1) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés de formule (I) dans laquelle R1, R2, R3, R4, R5, R6, et R7 ont la signification indiquée dans la description, ou un tautomère, un promédicament, un solvate, ou un sel de ceux-ci; des compositions pharmaceutiques contenant lesdits composés, et des procédés de modulation de la fonction du récepteur des glucocorticoïdes ainsi que des procédés de traitement d'états pathologiques ou de maladies à médiation assurée par la fonction du récepteur des glucocorticoïdes ou caractérisés par des processus inflammatoires, allergiques, ou prolifératifs chez un patient à l'aide de ces composés.

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