Bicyclic(azaaromatic)indoles as inhibitors of leukotriene...

Details Bicyclic(azaaromatic)indoles as inhibitors of leukotriene... Bicyclic(azaaromatic)indoles as inhibitors of leukotriene...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 209/30 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2136240

2136240 9325546 PCTABS00028 Compounds having formula (I) wherein Het is ArR1R2R3, Ar is a bicyclic aromatic 8- to 10-membered ring containing 1 to 3 N atoms, the tetrahydro derivatives thereof, and the N-oxides thereof, are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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