C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/55 (2006.01) A61P 25/06 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2672230
Compounds of formula I: I (wherein variables A1, m, R1, R2, R3, R4 and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés de formule (I) : (I) (dans laquelle les variables A1, m, R1, R2, R3, R4 et Z sont telles que décrites ici) qui sont des antagonistes des récepteurs du CGRP et qui sont utilisables pour le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué telles que la migraine. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions pour la prévention et le traitement des maladies dans lesquelles le CGRP est impliqué.
Bell Ian M.
Selnick Harold G.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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