Compositions and methods to prevent cancer with cupredoxins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/21 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) C07K 14/00 (2006.01) C07K 14/195 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2663498

The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.

La présente invention concerne des compositions constituées de peptides pouvant être des variantes, des dérivés et des équivalents structurels des cupredoxines qui inhibent le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens. De manière spécifique, ces compositions peuvent contenir de l'azurine de Pseudomonas aeruginosa, et/ou la région résiduelle 50-77 de l'azurine (p28). La présente invention concerne en outre des compositions qui peuvent contenir une ou plusieurs cupredoxines, et/ou des variantes, des dérivés ou des équivalents structurels des cupredoxines et peuvent conserver la capacité d'inhiber le développement de lésions prémalignes dans des cellules, des tissus ou des animaux mammaliens. Ces compositions peuvent, entre autres, être des peptides ou des compositions pharmaceutiques. Il est possible d'utiliser les compositions de l'invention pour prévenir le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens, et de ce fait prévenir le cancer.

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